Deruta, a medieval hilltown in Umbria, Italy, is mainly known as a major centre for the production of maiolica (painted tin-glazed earthenware) in the Renaissance and later. Production of pottery is documented in the early Middle Ages, though no surviving pieces can be firmly attributed there before about 1490. It reached its artistic peak in the 15th and early 16th century.

It was the first Italian centre to use lustreware pigments, usually yellow, ruby or olive-green. Open pieces are usually only painted the top side; both of these suggesting influence from Spain. Deruta istoriato designs (with narrative scenes) are less common than single figures, usually no more than half-length, and in both cases the central painted design rarely covers the whole surface, leaving room for a generous border painted with decorative motifs.

In 1553, Leandro Alberti wrote “... the terracotta vases made in Deruta are often mentioned for how well they are made and beautifully decorated. And it is believed that there are no other craftsmen in Italy that can match the work even though there have been attempts to do so...” However, it was just at this point that the quality of wares began to decline.

Some individual painters are known, but at the same time it is often difficult to assign pieces between Derauta and other centres, especially nearby Gubbio.

A characteristic local motif is the Deruta trademark "Raffaellesco" dragon design, said to be inspired by the murals of Raphael. An example of this dragon in Raphael's work can be seen in the painting "St Michael Killing the Dragon".